یکشنبه چهارم مهر ۱۳۸۹ - ۴:۳ ق.ظ - دکتر لیلا (مهستی) جویباری -
سوال: من35سال سن دارم و مبتلا به مگاکولون مشکوک به هیرشپرونگ میباشم که ممکن است بعد از مانومتری قطعا مشخص شود. آیا امکان درمان روده از طریق سلولهای بنیادین وجود دارد؟
پاسخ: لینک های زیر پاسخ سوال شماست.
لطفا یکی از دانشجویانی که در این ترم واحد کودکان دارند مطالب را ترجمه کنند.
نتیجه گیری یک مقاله :
شواهد جاری نشان میدهد پیوند سلول های بنیادی در بیماری هیرشپرونگ می تواند یک درمان الترناتیو باشد و برای بسیاری از موارد مادرزادی یا اکتسابی هیرشپرونگ به کار رود.
Current evidence suggests that transplantation of ENS stem cells, sourced from easily accessible postnatal gut, could be a viable alternative treatment for HSCR and ultimately for a number of other congenital or acquired ENS disorders
The possibility of stem cell transplantation into the aganglionic gut and the reactivation of dormant stem cells in the gut to regenerate the enteric nervous system are being actively investigated.35 Experiments have demonstrated that neural crest stem cells (NCSC) are present, even in the adult gut, and are capable of proliferation and differentiation. In addition, researchers have been able to inject neural crest stem cells and later identify them in the native rectum. Whether or not injected stem cells or reactivated native progenitor cells will have the capability to recreate a functional enteric nervous system remains to be elucidated.
The possibility of stem cell transplantation into the aganglionic gut and the reactivation of dormant stem cells in the gut to regenerate the enteric nervous system are being actively investigated.35 Experiments have demonstrated that neural crest stem cells (NCSC) are present, even in the adult gut, and are capable of proliferation and differentiation. In addition, researchers have been able to inject neural crest stem cells and later identify them in the native rectum. Whether or not injected stem cells or reactivated native progenitor cells will have the capability to recreate a functional enteric nervous system remains to be elucidated.
بسم الله الرحمن الرحیم